1blx Summary



The structure was published by Brotherton, D.H., Dhanaraj, V., Wick, S., et al., Brenner, S.L., Blundell, T.L., and Laue, E.D., in 1998 in a paper entitled "Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CYCLIN-DEPENDENT KINASE 6 and P19INK4D.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 6 Q00534 (1-326) (CDK6_HUMAN)search Homo sapienssearch 92% 326 93%
B P19INK4D Q60773 (1-166) (CDN2D_MOUSE)search Mus musculussearch 100% 166 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00534 (1 - 326) CYCLIN-DEPENDENT KINASE 6 Homo sapiens
Q60773 (1 - 166) P19INK4D Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q00534) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B (Q60773) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF12796: Ankyrin repeats (3 copies)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q00534) protein phosphorylationsearch regulation of cell proliferationsearch Notch signaling pathwaysearch lateral ventricle developmentsearch T cell differentiation in thymussearch gliogenesissearch generation of neuronssearch negative regulation of cell differentiationsearch negative regulation of cell proliferationsearch cell dedifferentiationsearch cell cyclesearch negative regulation of cell cyclesearch regulation of erythrocyte differentiationsearch negative regulation of epithelial cell proliferationsearch mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch cell divisionsearch cell differentiationsearch negative regulation of osteoblast differentiationsearch regulation of gene expressionsearch positive regulation of fibroblast proliferationsearch positive regulation of gene expressionsearch dentate gyrus developmentsearch negative regulation of cellular senescencesearch type B pancreatic cell developmentsearch positive regulation of cell-matrix adhesionsearch regulation of cell motilitysearch phosphorylationsearch hematopoietic stem cell differentiationsearch cell cycle arrestsearch astrocyte developmentsearch negative regulation of myeloid cell differentiationsearch response to virussearch hemopoiesissearch hematopoietic progenitor cell differentiationsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch ATP bindingsearch transferase activitysearch rufflesearch cytoplasmsearch nucleussearch nucleoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch cell projectionsearch
B (Q60773) cell cycle arrestsearch negative regulation of protein serine/threonine kinase activitysearch response to retinoic acidsearch autophagic cell deathsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch negative regulation of cell growthsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch cell cyclesearch negative regulation of cell proliferationsearch DNA synthesis involved in DNA repairsearch negative regulation of phosphorylationsearch response to UVsearch G1/S transition of mitotic cell cyclesearch sensory perception of soundsearch negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagesearch response to vitamin Dsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch protein kinase bindingsearch nucleussearch cytoplasmsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Cyclin-dependent kinase 6search
B Ankyrin repeatsearch Ankyrin repeat-containing domainsearch