› 1bjj

X-ray diffraction
2.8Å resolution

AGKISTRODOTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS

Released:
DOI: 10.2210/pdb1bjj/pdb
PDB entry 1bjj coloured by chain, front view.
PDB entry 1bjj coloured by chain, side view.
PDB entry 1bjj coloured by chain, top view.
Source organism: Gloydius halys
Primary publication:
Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit.
Tang L, Zhou YC, Lin ZJ
Acta Crystallogr D Biol Crystallogr 55 1986-96 (1999)
PMID: 10666574

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-146943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutral phospholipase A2 agkistrodotoxin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 122 amino acids
Theoretical weight: 14.01 KDa
Source organism: Gloydius halys
UniProt:
  • Canonical: P14421 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 87.75Å b: 105.8Å c: 110.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 0.26

Quick links

Citations

2 citation in other articles

Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom.
Marchi-Salvador et al. (2008)
1 more

3 mentions without citation

Association of putative concave protein-binding sites with the fluctuation behavior of residues.
Ertekin et al. (2006)
2 more