1bij Summary

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CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A

The structure was published by Fernandez, E.J., Abad-Zapatero, C., and Olsen, K.W., in 2000 in a paper entitled "Crystal structure of Lysbeta(1)82-Lysbeta(2)82 crosslinked hemoglobin: a possible allosteric intermediate" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch bicarbonate transportsearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch protein heterooligomerizationsearch small molecule metabolic processsearch
B, D (P68871) extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin bindingsearch heme bindingsearch metal ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen transportsearch transportsearch oxidation-reduction processsearch renal absorptionsearch nitric oxide transportsearch platelet aggregationsearch response to hydrogen peroxidesearch regulation of blood pressuresearch bicarbonate transportsearch blood coagulationsearch small molecule metabolic processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch