1bij Summary

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CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A

The structure was published by Fernandez, E.J., Abad-Zapatero, C., and Olsen, K.W., in 2000 in a paper entitled "Crystal structure of Lysbeta(1)82-Lysbeta(2)82 crosslinked hemoglobin: a possible allosteric intermediate" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch blood microparticlesearch extracellular vesicular exosomesearch extracellular regionsearch membranesearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch hemoglobin bindingsearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch heme bindingsearch oxygen transportsearch regulation of blood vessel sizesearch renal absorptionsearch response to hydrogen peroxidesearch nitric oxide transportsearch platelet aggregationsearch transportsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch blood coagulationsearch small molecule metabolic processsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch