1bij Summary

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CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A

The structure was published by Fernandez, E.J., Abad-Zapatero, C., and Olsen, K.W., in 2000 in a paper entitled "Crystal structure of Lysbeta(1)82-Lysbeta(2)82 crosslinked hemoglobin: a possible allosteric intermediate" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch extracellular regionsearch membranesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch transportsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch metal ion bindingsearch protein bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch oxygen transportsearch renal absorptionsearch oxidation-reduction processsearch platelet aggregationsearch response to hydrogen peroxidesearch regulation of blood pressuresearch nitric oxide transportsearch regulation of blood vessel sizesearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch blood coagulationsearch small molecule metabolic processsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch