1bic Summary

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CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-

The structure was published by Xue, Y., Vidgren, J., Svensson, L.A., Liljas, A., Jonsson, B.H., and Lindskog, S., in 1993 in a paper entitled "Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch one-carbon metabolic processsearch bicarbonate transportsearch response to pHsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch carbon dioxide transportsearch regulation of anion transportsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch response to estrogensearch positive regulation of cellular pH reductionsearch response to zinc ionsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch kidney developmentsearch secretionsearch response to organic substancesearch positive regulation of osteoclast differentiationsearch cytosolsearch plasma membranesearch basolateral plasma membranesearch cytoplasmsearch extracellular vesicular exosomesearch axonsearch extracellular spacesearch microvillussearch membranesearch apical part of cellsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch