› 1bht

X-ray diffraction
2Å resolution

NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR

Released:
DOI: 10.2210/pdb1bht/pdb
PDB entry 1bht coloured by chain, front view.
PDB entry 1bht coloured by chain, side view.
PDB entry 1bht coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Ultsch M, Lokker NA, Godowski PJ, de Vos AM
Structure 6 1383-93 (1998)
PMID: 9817840

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14210 (Residues: 35-210; Coverage: 25%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P43212
Unit cell:
a: 88.32Å b: 88.32Å c: 117.284Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.247
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Met, metastasis, motility and more.
Birchmeier et al. (2003)
4 more

12 mentions without citation

State of the structure address on MET receptor activation by HGF.
Linossi et al. (2021)
11 more