Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Tyrosine-protein kinase Lck (preferred)
PDBe Complex ID:
PDB-CPX-138949 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Lck
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P06239 (Residues: 119-226; Coverage: 21%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
Tyrosine-protein kinase Lck
Molecule details ›
Chain: B
Length: 103 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 103 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P06239 (Residues: 124-226; Coverage: 20%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RUH2R
Spacegroup:
P43212
Expression system: Escherichia coli
