1bhg Summary



The structure was published by Jain, S., Drendel, W.B., Chen, Z.W., Mathews, F.S., Sly, W.S., and Grubb, J.H., in 1996 in a paper entitled "Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.53 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of BETA-GLUCURONIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-GLUCURONIDASE P08236 (21-633) (BGLR_HUMAN)search Homo sapienssearch < 90% 613 99%
B BETA-GLUCURONIDASE P08236 (21-633) (BGLR_HUMAN)search Homo sapienssearch < 90% 613 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08236 (21 - 633) BETA-GLUCURONIDASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B beta-Galactosidase/glucuronidase domainsearch, beta-Galactosidase/glucuronidase, N-terminal domainsearch, beta-glycanasessearch Galactose-binding domain-likesearch, Immunoglobulin-likesearch, Glycosidasessearch Glycosyl hydrolases family 2search, Glycosyl hydrolases family 2, TIM barrel domainsearch, Glycosyl hydrolases family 2, sugar binding domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P08236) hydrolase activity, hydrolyzing O-glycosyl compoundssearch carbohydrate metabolic processsearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 2search Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwichsearch Glycoside hydrolase, family 2, TIM barrelsearch Glycosyl hydrolases family 2, sugar binding domainsearch Galactose-binding domain-likesearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domainsearch Glycoside hydrolase superfamilysearch Glycoside hydrolase, family 2, conserved sitesearch Glycoside hydrolase, family 2, active sitesearch