1bh2 Summary

pdbe.org/1bh2
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A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT

The structure was published by Posner, B.A., Mixon, M.B., Wall, M.A., Sprang, S.R., and Gilman, A.G., in 1998 in a paper entitled "The A326S mutant of Gialpha1 as an approximation of the receptor-bound state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of GUANINE NUCLEOTIDE-BINDING PROTEIN. This molecule has the UniProt identifier P10824 (GNAI1_RAT)search. The sample contained 315 residues which is < 90% of the natural sequence. Out of 315 residues 315 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GUANINE NUCLEOTIDE-BINDING PROTEIN P10824 (32-346) (GNAI1_RAT)search Rattus norvegicussearch 98% 315 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10824 (32 - 346) GUANINE NUCLEOTIDE-BINDING PROTEIN Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P10824) Transducin (alpha subunit), insertion domainsearch, G proteinssearch P-loop containing nucleotide triphosphate hydrolasessearch, GI Alpha 1, domain 2-likesearch PF00503: G-protein alpha subunitsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P10824) G-protein coupled receptor signaling pathwaysearch signal transductionsearch adenylate cyclase-modulating G-protein coupled receptor signaling pathwaysearch GTP catabolic processsearch G-protein beta/gamma-subunit complex bindingsearch signal transducer activitysearch GTPase activitysearch GTP bindingsearch guanyl nucleotide bindingsearch

Chain InterPro annotation
A Guanine nucleotide binding protein (G-protein), alpha subunitsearch G-protein alpha subunit, group Isearch G protein alpha subunit, helical insertionsearch P-loop containing nucleoside triphosphate hydrolasesearch