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SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE

The structure was published by Siegal, G., Davis, B., Kristensen, S.M., et al., Panayotou, G., Waterfield, M.D., and Driscoll, P.C., in 1998 in a paper entitled "Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of P85 ALPHA. This molecule has the UniProt identifier P23727 (P85A_BOVIN)search. The sample contained 112 residues which is < 90% of the natural sequence. Out of 112 residues 111 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P85 ALPHA P23727 (614-724) (P85A_BOVIN)search Bos taurussearch < 90% 112 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23727 (614 - 724) P85 ALPHA Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P23727) phosphatidylinositol 3-kinase regulator activitysearch phosphatidylinositol 3-kinase complexsearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch