1bd8 Summary

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STRUCTURE OF CDK INHIBITOR P19INK4D

The structure was published by Baumgartner, R., Fernandez-Catalan, C., Winoto, A., Huber, R., Engh, R.A., and Holak, T.A., in 1998 in a paper entitled "Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of P19INK4D CDK4/6 INHIBITOR. This molecule has the UniProt identifier P55273 (CDN2D_HUMAN)search. The sample contained 156 residues which is 94% of the natural sequence. Out of 156 residues 156 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P19INK4D CDK4/6 INHIBITOR P55273 (7-162) (CDN2D_HUMAN)search Homo sapienssearch 94% 156 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P55273 (7 - 162) P19INK4D CDK4/6 INHIBITOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P55273) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P55273) cytoplasmsearch nucleussearch cytosolsearch G1/S transition of mitotic cell cyclesearch autophagic cell deathsearch cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch negative regulation of cell growthsearch response to vitamin Dsearch negative regulation of phosphorylationsearch negative regulation of protein serine/threonine kinase activitysearch DNA synthesis involved in DNA repairsearch response to retinoic acidsearch negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagesearch sensory perception of soundsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch negative regulation of cell proliferationsearch mitotic cell cyclesearch response to UVsearch cell cycle arrestsearch protein kinase bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch

Chain InterPro annotation
A Ankyrin repeatsearch Ankyrin repeat-containing domainsearch