1bcd Summary

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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE

The structure was published by Hakansson, K. and Liljas, A., in 1994 in a paper entitled "The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch cytosolsearch basolateral plasma membranesearch extracellular vesicular exosomesearch plasma membranesearch cytoplasmsearch axonsearch membranesearch extracellular spacesearch apical part of cellsearch myelin sheathsearch microvillussearch secretionsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to organic substancesearch one-carbon metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch positive regulation of osteoclast differentiationsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch response to zinc ionsearch response to steroid hormonesearch regulation of chloride transportsearch response to estrogensearch kidney developmentsearch odontogenesis of dentin-containing toothsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch