1bbb Summary

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A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION

The structure was published by Silva, M.M., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "A third quaternary structure of human hemoglobin A at 1.7-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN A (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch iron ion bindingsearch haptoglobin bindingsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch membranesearch extracellular vesicular exosomesearch hemoglobin complexsearch blood microparticlesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch oxygen transportsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch positive regulation of cell deathsearch bicarbonate transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch peroxidase activitysearch cytosolsearch blood microparticlesearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch nitric oxide transportsearch renal absorptionsearch regulation of blood pressuresearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch receptor-mediated endocytosissearch oxidation-reduction processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch