› 1bbb

X-ray diffraction
1.7Å resolution

A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1bbb/pdb
PDB entry 1bbb coloured by chain, front view.
PDB entry 1bbb coloured by chain, side view.
PDB entry 1bbb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A third quaternary structure of human hemoglobin A at 1.7-A resolution.
Silva MM, Rogers PH, Arnone A
J Biol Chem 267 17248-56 (1992)
PMID: 1512262

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand CMO 4 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 97.5Å b: 101.5Å c: 61.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 not available not available
Expression system: Not provided

Quick links

Citations

12 review citations

The ensemble nature of allostery.
Motlagh et al. (2014)
11 more

51 mentions without citation

Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation.
Bahar et al. (2007)
50 more