1bab Summary

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HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS

The structure was published by Vasseur, C., Blouquit, Y., Kister, J., et al., Poyart, C., Rosa, J., and Wajcman, H., in 1992 in a paper entitled "Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
C HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
B HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (1 - 142) HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch oxygen transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch bicarbonate transportsearch positive regulation of cell deathsearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch hemoglobin complexsearch blood microparticlesearch extracellular regionsearch extracellular exosomesearch membranesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch protein bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch protein heterooligomerizationsearch oxygen transportsearch small molecule metabolic processsearch nitric oxide transportsearch response to hydrogen peroxidesearch renal absorptionsearch platelet aggregationsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch regulation of blood pressuresearch blood coagulationsearch receptor-mediated endocytosissearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch extracellular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch