1bab Summary

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HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS

The structure was published by Vasseur, C., Blouquit, Y., Kister, J., et al., Poyart, C., Rosa, J., and Wajcman, H., in 1992 in a paper entitled "Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
C HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
B HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (1 - 142) HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch extracellular regionsearch blood microparticlesearch extracellular vesicular exosomesearch cytosolsearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch transportsearch positive regulation of cell deathsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch oxygen transportsearch small molecule metabolic processsearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch platelet aggregationsearch oxygen transportsearch regulation of blood pressuresearch small molecule metabolic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch positive regulation of cell deathsearch blood coagulationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch