1bab Summary

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HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS

The structure was published by Vasseur, C., Blouquit, Y., Kister, J., et al., Poyart, C., Rosa, J., and Wajcman, H., in 1992 in a paper entitled "Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
C HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 143 100%
B HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (1 - 142) HEMOGLOBIN THIONVILLE (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN THIONVILLE (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch protein bindingsearch oxygen bindingsearch iron ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch blood microparticlesearch extracellular regionsearch cytosolsearch membranesearch endocytic vesicle lumensearch
B, D (P68871) heme bindingsearch haptoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch iron ion bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch bicarbonate transportsearch oxygen transportsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch oxidation-reduction processsearch small molecule metabolic processsearch regulation of blood pressuresearch nitric oxide transportsearch response to hydrogen peroxidesearch platelet aggregationsearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch blood coagulationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch