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Histidine ammonia-lyase (HAL) from Pseudomonas putida

Source organism: Pseudomonas putida
Biochemical function: ammonia-lyase activity
Biological process: histidine catabolic process to glutamate and formate
Cellular component: cytoplasm

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EC 4.3.1.3: Histidine ammonia-lyase

Reaction catalysed:
L-histidine = urocanate + NH(3)
Systematic name:
L-histidine ammonia-lyase (urocanate-forming)
Alternative Name(s):
  • Histidase
  • Histidinase
  • Histidine alpha-deaminase
  • L-histidine ammonia-lyase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00221
Domain description: Aromatic amino acid lyase
Occurring in:
  1. Histidine ammonia-lyase
The deposited structure of PDB entry 1b8f contains 1 copy of Pfam domain PF00221 (Aromatic amino acid lyase) in Histidine ammonia-lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001106
Domain description: Aromatic amino acid lyase
Occurring in:
  1. Histidine ammonia-lyase
IPR022313
Domain description: Phenylalanine/histidine ammonia-lyases, active site
Occurring in:
  1. Histidine ammonia-lyase
IPR008948
Domain description: L-Aspartase-like
Occurring in:
  1. Histidine ammonia-lyase
IPR005921
Domain description: Histidine ammonia-lyase
Occurring in:
  1. Histidine ammonia-lyase
IPR024083
Domain description: Fumarase/histidase, N-terminal
Occurring in:
  1. Histidine ammonia-lyase

Structure domains

CATH CATH domains
1.20.200.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Fumarase C; Chain A, domain 2
Homology: Fumarase/aspartase (Central domain)
Occurring in:
  1. Histidine ammonia-lyase
The deposited structure of PDB entry 1b8f contains 1 copy of CATH domain 1.20.200.10 (Fumarase C; Chain A, domain 2) in Histidine ammonia-lyase. Showing 1 copy in chain A.
1.10.275.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Fumarase C; Chain B, domain 1
Homology: Fumarase/aspartase (N-terminal domain)
Occurring in:
  1. Histidine ammonia-lyase
The deposited structure of PDB entry 1b8f contains 1 copy of CATH domain 1.10.275.10 (Fumarase C; Chain B, domain 1) in Histidine ammonia-lyase. Showing 1 copy in chain A.
SCOP SCOP annotation
48572
Class: All alpha proteins
Fold: L-aspartase-like
Superfamily: L-aspartase-like
Occurring in:
  1. Histidine ammonia-lyase
The deposited structure of PDB entry 1b8f contains 1 copy of SCOP domain 48572 (HAL/PAL-like) in Histidine ammonia-lyase. Showing 1 copy in chain A.

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