1b86 Summary

pdbe.org/1b86
spacer

HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX

The structure was published by Richard, V., Dodson, G.G., and Mauguen, Y., in 1993 in a paper entitled "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN; ALPHA CHAIN) and PROTEIN (HEMOGLOBIN; BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN; ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN; BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch transportsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch
B, D (P68871) regulation of blood pressuresearch oxygen transportsearch transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch nitric oxide transportsearch platelet aggregationsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch renal absorptionsearch oxidation-reduction processsearch regulation of blood vessel sizesearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch heme bindingsearch oxygen bindingsearch hemoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch