1b86 Summary

pdbe.org/1b86
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HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX

The structure was published by Richard, V., Dodson, G.G., and Mauguen, Y., in 1993 in a paper entitled "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN; ALPHA CHAIN) and PROTEIN (HEMOGLOBIN; BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN; ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN; BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch membranesearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch oxygen transportsearch
B, D (P68871) hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch iron ion bindingsearch heme bindingsearch hemoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch platelet aggregationsearch regulation of blood vessel sizesearch nitric oxide transportsearch renal absorptionsearch blood coagulationsearch transportsearch regulation of blood pressuresearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch