1b86 Summary

pdbe.org/1b86
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HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX

The structure was published by Richard, V., Dodson, G.G., and Mauguen, Y., in 1993 in a paper entitled "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN; ALPHA CHAIN) and PROTEIN (HEMOGLOBIN; BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN; ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN; BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxidation-reduction processsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch transportsearch hemoglobin complexsearch extracellular exosomesearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch membranesearch
B, D (P68871) heme bindingsearch iron ion bindingsearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch nitric oxide transportsearch bicarbonate transportsearch regulation of blood pressuresearch platelet aggregationsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch blood coagulationsearch renal absorptionsearch hydrogen peroxide catabolic processsearch transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch regulation of blood vessel sizesearch cytosolsearch extracellular exosomesearch blood microparticlesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch