1b86 Summary

pdbe.org/1b86
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HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX

The structure was published by Richard, V., Dodson, G.G., and Mauguen, Y., in 1993 in a paper entitled "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN; ALPHA CHAIN) and PROTEIN (HEMOGLOBIN; BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN; ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN; BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch transportsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch heme bindingsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch
B, D (P68871) transportsearch protein heterooligomerizationsearch oxygen transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch regulation of blood vessel sizesearch bicarbonate transportsearch oxidation-reduction processsearch nitric oxide transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch blood coagulationsearch positive regulation of cell deathsearch regulation of blood pressuresearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch