1b86 Summary

pdbe.org/1b86
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HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX

The structure was published by Richard, V., Dodson, G.G., and Mauguen, Y., in 1993 in a paper entitled "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN; ALPHA CHAIN) and PROTEIN (HEMOGLOBIN; BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN; ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN; BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN; ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN; BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch oxidation-reduction processsearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch oxygen transportsearch response to hydrogen peroxidesearch extracellular regionsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch platelet aggregationsearch nitric oxide transportsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch renal absorptionsearch regulation of blood pressuresearch positive regulation of cell deathsearch blood coagulationsearch regulation of blood vessel sizesearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch