1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 97% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 97% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P10147) extracellular regionsearch extracellular spacesearch cytoplasmsearch intracellularsearch cytosolsearch chemokine activitysearch CCR1 chemokine receptor bindingsearch chemoattractant activitysearch CCR5 chemokine receptor bindingsearch calcium-dependent protein kinase C activitysearch identical protein bindingsearch cytokine activitysearch protein bindingsearch protein kinase activitysearch kinase activitysearch phospholipase activator activitysearch immune responsesearch positive regulation of gene expressionsearch astrocyte cell migrationsearch neutrophil chemotaxissearch inflammatory responsesearch cellular calcium ion homeostasissearch cellular response to tumor necrosis factorsearch positive chemotaxissearch calcium ion transportsearch granulocyte chemotaxissearch MAPK cascadesearch positive regulation of calcium ion transportsearch exocytosissearch negative regulation of bone mineralizationsearch monocyte chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch signalingsearch positive regulation of cell migrationsearch macrophage chemotaxissearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search negative regulation by host of viral transcriptionsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of protein kinase B signalingsearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch regulation of sensory perception of painsearch positive regulation of inflammatory responsesearch cytoskeleton organizationsearch T cell chemotaxissearch chemotaxissearch calcium-mediated signalingsearch eosinophil chemotaxissearch osteoblast differentiationsearch protein phosphorylationsearch cell activationsearch behaviorsearch cellular response to interferon-gammasearch positive regulation of natural killer cell chemotaxissearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch protein kinase B signalingsearch response to cholesterolsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch positive regulation of catalytic activitysearch lymphocyte chemotaxissearch cell-cell signalingsearch negative regulation of gene expressionsearch lipopolysaccharide-mediated signaling pathwaysearch response to toxic substancesearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch