1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P10147) cytoplasmsearch intracellularsearch cytosolsearch extracellular spacesearch extracellular regionsearch cell activationsearch behaviorsearch calcium-mediated signalingsearch positive chemotaxissearch inflammatory responsesearch positive regulation of cell migrationsearch cellular response to interferon-gammasearch positive regulation of natural killer cell chemotaxissearch osteoblast differentiationsearch MAPK cascadesearch eosinophil chemotaxissearch chemotaxissearch cell-cell signalingsearch negative regulation of gene expressionsearch response to toxic substancesearch positive regulation of catalytic activitysearch immune responsesearch cellular calcium ion homeostasissearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch protein phosphorylationsearch monocyte chemotaxissearch lipopolysaccharide-mediated signaling pathwaysearch lymphocyte chemotaxissearch positive regulation of calcium ion transportsearch response to cholesterolsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch protein kinase B signalingsearch exocytosissearch negative regulation of bone mineralizationsearch granulocyte chemotaxissearch positive regulation of gene expressionsearch astrocyte cell migrationsearch calcium ion transportsearch cellular response to tumor necrosis factorsearch neutrophil chemotaxissearch cytoskeleton organizationsearch T cell chemotaxissearch positive regulation of inflammatory responsesearch signalingsearch macrophage chemotaxissearch negative regulation by host of viral transcriptionsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of protein kinase B signalingsearch regulation of sensory perception of painsearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search positive regulation of ERK1 and ERK2 cascadesearch chemoattractant activitysearch protein bindingsearch CCR1 chemokine receptor bindingsearch protein kinase activitysearch identical protein bindingsearch phospholipase activator activitysearch kinase activitysearch CCR5 chemokine receptor bindingsearch cytokine activitysearch chemokine activitysearch calcium-dependent protein kinase C activitysearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch