1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P10147) chemokine activitysearch CCR1 chemokine receptor bindingsearch chemoattractant activitysearch calcium-dependent protein kinase C activitysearch CCR5 chemokine receptor bindingsearch protein bindingsearch phospholipase activator activitysearch identical protein bindingsearch protein kinase activitysearch cytokine activitysearch kinase activitysearch immune responsesearch neutrophil chemotaxissearch exocytosissearch negative regulation of bone mineralizationsearch positive chemotaxissearch positive regulation of catalytic activitysearch granulocyte chemotaxissearch cellular calcium ion homeostasissearch cellular response to tumor necrosis factorsearch positive regulation of gene expressionsearch astrocyte cell migrationsearch calcium ion transportsearch MAPK cascadesearch positive regulation of calcium ion transportsearch positive regulation of inflammatory responsesearch inflammatory responsesearch cytoskeleton organizationsearch T cell chemotaxissearch protein phosphorylationsearch positive regulation of interleukin-1 beta secretionsearch negative regulation by host of viral transcriptionsearch positive regulation of protein kinase B signalingsearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch regulation of sensory perception of painsearch monocyte chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search signalingsearch positive regulation of cell migrationsearch macrophage chemotaxissearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch positive regulation of natural killer cell chemotaxissearch cell activationsearch behaviorsearch cellular response to interferon-gammasearch calcium-mediated signalingsearch osteoblast differentiationsearch chemotaxissearch eosinophil chemotaxissearch cell-cell signalingsearch negative regulation of gene expressionsearch lipopolysaccharide-mediated signaling pathwaysearch lymphocyte chemotaxissearch response to cholesterolsearch response to toxic substancesearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch protein kinase B signalingsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch extracellular regionsearch extracellular spacesearch intracellularsearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch