1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P10147) chemokine activitysearch CCR1 chemokine receptor bindingsearch chemoattractant activitysearch cytokine activitysearch protein bindingsearch identical protein bindingsearch calcium-dependent protein kinase C activitysearch CCR5 chemokine receptor bindingsearch kinase activitysearch phospholipase activator activitysearch protein kinase activitysearch immune responsesearch neutrophil chemotaxissearch protein phosphorylationsearch cellular calcium ion homeostasissearch cellular response to tumor necrosis factorsearch positive regulation of gene expressionsearch astrocyte cell migrationsearch calcium ion transportsearch exocytosissearch negative regulation of bone mineralizationsearch positive chemotaxissearch inflammatory responsesearch cytoskeleton organizationsearch T cell chemotaxissearch positive regulation of catalytic activitysearch positive regulation of inflammatory responsesearch granulocyte chemotaxissearch MAPK cascadesearch positive regulation of calcium ion transportsearch regulation of sensory perception of painsearch positive regulation of protein kinase B signalingsearch negative regulation by host of viral transcriptionsearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch chemotaxissearch positive regulation of interleukin-1 beta secretionsearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch monocyte chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch signalingsearch positive regulation of cell migrationsearch macrophage chemotaxissearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search calcium-mediated signalingsearch cell activationsearch behaviorsearch positive regulation of natural killer cell chemotaxissearch cellular response to interferon-gammasearch eosinophil chemotaxissearch osteoblast differentiationsearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch response to toxic substancesearch protein kinase B signalingsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch cell-cell signalingsearch negative regulation of gene expressionsearch response to cholesterolsearch lipopolysaccharide-mediated signaling pathwaysearch lymphocyte chemotaxissearch extracellular regionsearch extracellular spacesearch intracellularsearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch