1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P10147) chemokine activitysearch CCR1 chemokine receptor bindingsearch chemoattractant activitysearch CCR5 chemokine receptor bindingsearch protein bindingsearch calcium-dependent protein kinase C activitysearch identical protein bindingsearch phospholipase activator activitysearch kinase activitysearch cytokine activitysearch protein kinase activitysearch extracellular regionsearch extracellular spacesearch cytoplasmsearch intracellularsearch cytosolsearch immune responsesearch cellular calcium ion homeostasissearch cellular response to tumor necrosis factorsearch neutrophil chemotaxissearch calcium ion transportsearch positive regulation of gene expressionsearch astrocyte cell migrationsearch protein phosphorylationsearch positive chemotaxissearch positive regulation of inflammatory responsesearch chemotaxissearch exocytosissearch negative regulation of bone mineralizationsearch granulocyte chemotaxissearch MAPK cascadesearch positive regulation of calcium ion transportsearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search monocyte chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch signalingsearch positive regulation of cell migrationsearch macrophage chemotaxissearch inflammatory responsesearch cytoskeleton organizationsearch T cell chemotaxissearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch positive regulation of protein kinase B signalingsearch regulation of sensory perception of painsearch negative regulation by host of viral transcriptionsearch positive regulation of interleukin-1 beta secretionsearch cell activationsearch behaviorsearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch positive regulation of catalytic activitysearch cellular response to interferon-gammasearch positive regulation of natural killer cell chemotaxissearch calcium-mediated signalingsearch eosinophil chemotaxissearch osteoblast differentiationsearch response to cholesterolsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch response to toxic substancesearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch lymphocyte chemotaxissearch cell-cell signalingsearch negative regulation of gene expressionsearch protein kinase B signalingsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch