1b53 Summary

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NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE

The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P10147) chemokine activitysearch CCR1 chemokine receptor bindingsearch chemoattractant activitysearch cytokine activitysearch CCR5 chemokine receptor bindingsearch identical protein bindingsearch calcium-dependent protein kinase C activitysearch protein bindingsearch phospholipase activator activitysearch kinase activitysearch protein kinase activitysearch extracellular regionsearch extracellular spacesearch intracellularsearch cytosolsearch cytoplasmsearch immune responsesearch neutrophil chemotaxissearch cellular calcium ion homeostasissearch cellular response to tumor necrosis factorsearch positive chemotaxissearch inflammatory responsesearch calcium ion transportsearch positive regulation of gene expressionsearch astrocyte cell migrationsearch MAPK cascadesearch positive regulation of calcium ion transportsearch protein phosphorylationsearch exocytosissearch negative regulation of bone mineralizationsearch granulocyte chemotaxissearch chemotaxissearch positive regulation of inflammatory responsesearch cellular response to organic cyclic compoundsearch positive regulation of calcium ion importsearch cytoskeleton organizationsearch T cell chemotaxissearch negative regulation by host of viral transcriptionsearch regulation of sensory perception of painsearch positive regulation of protein kinase B signalingsearch positive regulation of calcium-mediated signalingsearch cellular response to interleukin-1search positive regulation of interleukin-1 beta secretionsearch signalingsearch positive regulation of cell migrationsearch macrophage chemotaxissearch monocyte chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch eosinophil degranulationsearch cellular response to interferon-gammasearch positive regulation of natural killer cell chemotaxissearch calcium-mediated signalingsearch positive regulation of catalytic activitysearch regulation of cell shapesearch negative regulation of osteoclast differentiationsearch osteoblast differentiationsearch cell activationsearch behaviorsearch eosinophil chemotaxissearch cell-cell signalingsearch negative regulation of gene expressionsearch response to toxic substancesearch lipopolysaccharide-mediated signaling pathwaysearch protein kinase B signalingsearch lymphocyte chemotaxissearch response to cholesterolsearch positive regulation of tumor necrosis factor productionsearch positive regulation of neuron apoptotic processsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch