1b53 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 100% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P10147) MAPK cascadesearch osteoblast differentiationsearch cell activationsearch monocyte chemotaxissearch protein phosphorylationsearch calcium ion transportsearch cellular calcium ion homeostasissearch exocytosissearch chemotaxissearch inflammatory responsesearch immune responsesearch cytoskeleton organizationsearch cell-cell signalingsearch behaviorsearch regulation of cell shapesearch response to toxic substancesearch positive regulation of gene expressionsearch negative regulation of gene expressionsearch T cell chemotaxissearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch calcium-mediated signalingsearch signalingsearch positive regulation of cell migrationsearch negative regulation of bone mineralizationsearch neutrophil chemotaxissearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of tumor necrosis factor productionsearch positive regulation of catalytic activitysearch eosinophil degranulationsearch protein kinase B signalingsearch positive regulation of neuron apoptotic processsearch astrocyte cell migrationsearch negative regulation by host of viral transcriptionsearch negative regulation of osteoclast differentiationsearch eosinophil chemotaxissearch macrophage chemotaxissearch lymphocyte chemotaxissearch positive regulation of interleukin-1 beta secretionsearch positive regulation of inflammatory responsesearch positive regulation of calcium-mediated signalingsearch positive chemotaxissearch positive regulation of protein kinase B signalingsearch positive regulation of calcium ion transportsearch regulation of sensory perception of painsearch positive regulation of ERK1 and ERK2 cascadesearch response to cholesterolsearch cellular response to interferon-gammasearch cellular response to interleukin-1search cellular response to tumor necrosis factorsearch cellular response to organic cyclic compoundsearch granulocyte chemotaxissearch positive regulation of calcium ion importsearch positive regulation of natural killer cell chemotaxissearch protein kinase activitysearch calcium-dependent protein kinase C activitysearch cytokine activitysearch protein bindingsearch chemokine activitysearch phospholipase activator activitysearch kinase activitysearch CCR1 chemokine receptor bindingsearch CCR5 chemokine receptor bindingsearch chemoattractant activitysearch identical protein bindingsearch extracellular regionsearch extracellular spacesearch intracellularsearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch