1b50 Summary



The structure was published by Czaplewski, L.G., McKeating, J., Craven, C.J., et al., Fisher, J., Waltho, J.P., and Hunter, M.G., in 1999 in a paper entitled "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MIP-1A.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 97% 69 100%
B MIP-1A P10147 (24-92) (CCL3_HUMAN)search Homo sapienssearch 97% 69 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10147 (24 - 92) MIP-1A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P10147) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P10147) chemokine activitysearch protein bindingsearch calcium-dependent protein kinase C activitysearch CCR5 chemokine receptor bindingsearch chemoattractant activitysearch CCR1 chemokine receptor bindingsearch protein kinase activitysearch phospholipase activator activitysearch kinase activitysearch cytokine activitysearch identical protein bindingsearch cytosolsearch extracellular spacesearch intracellularsearch extracellular regionsearch cytoplasmsearch eosinophil degranulationsearch calcium-mediated signalingsearch inflammatory responsesearch response to cholesterolsearch lymphocyte chemotaxissearch protein phosphorylationsearch cellular calcium ion homeostasissearch cellular response to interferon-gammasearch positive regulation of protein kinase B signalingsearch positive chemotaxissearch neutrophil chemotaxissearch positive regulation of calcium ion transportsearch granulocyte chemotaxissearch monocyte chemotaxissearch eosinophil chemotaxissearch protein kinase B signalingsearch osteoblast differentiationsearch negative regulation of gene expressionsearch positive regulation of calcium ion importsearch calcium ion transportsearch positive regulation of tumor necrosis factor productionsearch regulation of sensory perception of painsearch chemotaxissearch signalingsearch positive regulation of cell migrationsearch negative regulation by host of viral transcriptionsearch immune responsesearch negative regulation of osteoclast differentiationsearch positive regulation of ERK1 and ERK2 cascadesearch behaviorsearch cell-cell signalingsearch cellular response to tumor necrosis factorsearch lipopolysaccharide-mediated signaling pathwaysearch release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch positive regulation of natural killer cell chemotaxissearch positive regulation of calcium-mediated signalingsearch positive regulation of gene expressionsearch cell activationsearch astrocyte cell migrationsearch positive regulation of interleukin-1 beta secretionsearch negative regulation of bone mineralizationsearch cellular response to organic cyclic compoundsearch positive regulation of catalytic activitysearch positive regulation of neuron apoptotic processsearch MAPK cascadesearch cytoskeleton organizationsearch regulation of cell shapesearch cellular response to interleukin-1search positive regulation of inflammatory responsesearch exocytosissearch response to toxic substancesearch T cell chemotaxissearch macrophage chemotaxissearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch