1b4v Summary



The structure was published by Yue, Q.K., Kass, I.J., Sampson, N.S., and Vrielink, A., in 1999 in a paper entitled "Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (CHOLESTEROL OXIDASE). This molecule has the UniProt identifier P12676 (CHOD_STRS0)search. The sample contained 504 residues which is 100% of the natural sequence. Out of 504 residues 497 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CHOLESTEROL OXIDASE) P12676 (43-546) (CHOD_STRS0)search Streptomyces sp. SA-COOsearch 98% 504 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12676 (43 - 546) PROTEIN (CHOLESTEROL OXIDASE) Streptomyces sp.

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12676) FAD-linked reductases, N-terminal domainsearch, GMC oxidoreductasessearch FAD/NAD(P)-binding domainsearch, Cholesterol Oxidase; domain 2search PF00732: GMC oxidoreductasesearch, PF05199: GMC oxidoreductasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P12676) oxidoreductase activitysearch cholesterol oxidase activitysearch isomerase activitysearch oxidoreductase activity, acting on CH-OH group of donorssearch flavin adenine dinucleotide bindingsearch steroid delta-isomerase activitysearch steroid metabolic processsearch oxidation-reduction processsearch lipid metabolic processsearch cholesterol metabolic processsearch extracellular regionsearch

Chain InterPro annotation
A Glucose-methanol-choline oxidoreductase, N-terminalsearch Glucose-methanol-choline oxidoreductase, C-terminalsearch