1b47 Summary

pdbe.org/1b47
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STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70

The structure was published by Meng, W., Sawasdikosol, S., Burakoff, S.J., and Eck, M.J., in 1999 in a paper entitled "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CBL.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CBL P22681 (47-350) (CBL_HUMAN)search Homo sapienssearch < 90% 304 100%
B CBL P22681 (47-350) (CBL_HUMAN)search Homo sapienssearch < 90% 304 100%
C CBL P22681 (47-350) (CBL_HUMAN)search Homo sapienssearch < 90% 304 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22681 (47 - 350) CBL Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C EF-hand modules in multidomain proteinssearch, N-terminal domain of cbl (N-cbl)search, SH2 domainsearch Transcription Elongation Factor S-II; Chain Asearch, EF-handsearch, SHC Adaptor Proteinsearch CBL proto-oncogene N-terminal domain 1search, CBL proto-oncogene N-terminus, EF hand-like domainsearch, CBL proto-oncogene N-terminus, SH2-like domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C (P22681) cell surface receptor signaling pathwaysearch regulation of signalingsearch signal transducer activitysearch ubiquitin-protein transferase activitysearch phosphotyrosine bindingsearch calcium ion bindingsearch nucleussearch

Chain InterPro annotation
A, B, C SH2 domainsearch Adaptor protein Cbl, N-terminal helicalsearch EF-hand domain pairsearch Adaptor protein Cbl, EF hand-likesearch Adaptor protein Cbl, SH2-likesearch Adaptor protein Cbl, PTB domainsearch Adaptor protein Cblsearch