1b41 Summary



There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Kryger, G., Harel, M., Giles, K., et al., Shafferman, A., Silman, I., and Sussman, J.L., in 2000 in a paper entitled "Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.76 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ACETYLCHOLINESTERASE and FASCICULIN-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ACETYLCHOLINESTERASE P22303 (36-574) (ACES_HUMAN)search Homo sapienssearch 92% 539 98%
B FASCICULIN-2 P0C1Z0 (1-61) (TXFA2_DENAN)search Dendroaspis angusticepssearch 100% 61 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P22303 (36 - 574) ACETYLCHOLINESTERASE Homo sapiens
P0C1Z0 (1 - 61) FASCICULIN-2 Dendroaspis angusticeps

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P22303) Acetylcholinesterase-likesearch Rossmann foldsearch PF00135: Carboxylesterase familysearch
B (P0C1Z0) Snake venom toxinssearch CD59search PF00087: Snake toxinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P22303) protein bindingsearch acetylcholinesterase activitysearch acetylcholine bindingsearch cholinesterase activitysearch serine hydrolase activitysearch collagen bindingsearch hydrolase activitysearch protein self-associationsearch beta-amyloid bindingsearch laminin bindingsearch protein homodimerization activitysearch carboxylic ester hydrolase activitysearch Golgi apparatussearch neuromuscular junctionsearch cell surfacesearch basal laminasearch perinuclear region of cytoplasmsearch synapsesearch extracellular regionsearch dendritesearch cell junctionsearch anchored component of membranesearch extracellular spacesearch membranesearch plasma membranesearch axonsearch presynaptic membranesearch nucleussearch postsynaptic membranesearch endoplasmic reticulum lumensearch retina development in camera-type eyesearch phospholipid metabolic processsearch positive regulation of protein secretionsearch negative regulation of synaptic transmission, cholinergicsearch regulation of axonogenesissearch phosphatidylcholine biosynthetic processsearch regulation of receptor recyclingsearch synaptic transmissionsearch cell proliferationsearch acetylcholine catabolic processsearch glycerophospholipid biosynthetic processsearch synapse assemblysearch amyloid precursor protein metabolic processsearch nervous system developmentsearch receptor internalizationsearch choline metabolic processsearch small molecule metabolic processsearch DNA replicationsearch neurotransmitter catabolic processsearch muscle organ developmentsearch cell adhesionsearch response to woundingsearch osteoblast developmentsearch neurotransmitter receptor biosynthetic processsearch neurotransmitter biosynthetic processsearch protein tetramerizationsearch regulation of dendrite morphogenesissearch synaptic transmission, cholinergicsearch acetylcholine catabolic process in synaptic cleftsearch
B (P0C1Z0) extracellular regionsearch modification of morphology or physiology of other organismsearch

Chain InterPro annotation
A Cholinesterasesearch Carboxylesterase, type Bsearch Acetylcholinesterase, tetramerisation domainsearch Carboxylesterase type B, conserved sitesearch Carboxylesterase type B, active sitesearch Alpha/Beta hydrolase foldsearch
B Snake toxinsearch Snake toxin binding sitesearch