1b39 Summary



The structure was published by Brown, N.R., Noble, M.E., Lawrie, A.M., et al., Divita, G., Johnson, L.N., and Endicott, J.A., in 1999 in a paper entitled "Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (CELL DIVISION PROTEIN KINASE 2). This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CELL DIVISION PROTEIN KINASE 2) P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) PROTEIN (CELL DIVISION PROTEIN KINASE 2) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch protein bindingsearch ATP bindingsearch metal ion bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch cyclin bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch cellular response to DNA damage stimulussearch potassium ion transportsearch histone phosphorylationsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch G1/S transition of mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch meiotic cell cyclesearch DNA replicationsearch phosphorylationsearch meiotic nuclear divisionsearch peptidyl-serine phosphorylationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of DNA-dependent DNA replication initiationsearch cell cyclesearch regulation of gene silencingsearch Ras protein signal transductionsearch mitotic nuclear divisionsearch DNA repairsearch mitotic G1 DNA damage checkpointsearch cellular response to nitric oxidesearch cell divisionsearch centrosome duplicationsearch nucleoplasmsearch cytoplasmsearch cytosolsearch cytoskeletonsearch Cajal bodysearch endosomesearch X chromosomesearch centrosomesearch condensed chromosomesearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch chromosome, telomeric regionsearch transcription factor complexsearch Y chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch