1b38 Summary



The structure was published by Brown, N.R., Noble, M.E., Lawrie, A.M., et al., Divita, G., Johnson, L.N., and Endicott, J.A., in 1999 in a paper entitled "Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (CELL DIVISION PROTEIN KINASE 2). This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CELL DIVISION PROTEIN KINASE 2) P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) PROTEIN (CELL DIVISION PROTEIN KINASE 2) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P24941) nucleoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch centrosomesearch cytosolsearch Cajal bodysearch nucleussearch cytoplasmsearch endosomesearch chromosome, telomeric regionsearch Y chromosomesearch cytoskeletonsearch X chromosomesearch transcription factor complexsearch condensed chromosomesearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch ATP bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch histone kinase activitysearch transferase activitysearch metal ion bindingsearch positive regulation of DNA-dependent DNA replication initiationsearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch phosphorylationsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch DNA replicationsearch cellular response to DNA damage stimulussearch cell divisionsearch positive regulation of cell proliferationsearch protein phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic cell cyclesearch centrosome duplicationsearch mitotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch meiotic nuclear divisionsearch regulation of gene silencingsearch cellular response to nitric oxidesearch cell cyclesearch meiotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch histone phosphorylationsearch potassium ion transportsearch DNA repairsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch