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PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.98 COORDINATES)

X-ray diffraction
1.9Å resolution
PDB entry 1b2f coloured by chain, front view.
PDB entry 1b2f coloured by chain, side view.
PDB entry 1b2f coloured by chain, top view.
Source organism: Sus scrofa
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3421.47 Å2
Buried surface area: 1550.18 Å2
Dissociation area: 775.09 Å2
Dissociation energy (ΔGdiss): 10.16 kcal/mol
Dissociation entropy (TΔSdiss): 8.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 2
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 5580.77 Å2
Buried surface area: 4362.53 Å2
Dissociation area: 632.73 Å2
Dissociation energy (ΔGdiss): 1.19 kcal/mol
Dissociation entropy (TΔSdiss): 9.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1b2f, assembly 1, front view.
Insulin A chain in PDB entry 1b2f, assembly 1, side view.
Insulin A chain in PDB entry 1b2f, assembly 1, top view.
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Insulin B chain
Chain: B
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 25-54; Coverage: 36%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1b2f, assembly 1, front view.
Insulin B chain in PDB entry 1b2f, assembly 1, side view.
Insulin B chain in PDB entry 1b2f, assembly 1, top view.
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