1b18 Summary

pdbe.org/1b18
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PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES)

The structure was published by Diao, J., in 2003 in a paper entitled "Crystallographic titration of cubic insulin crystals: pH affects GluB13 switching and sulfate binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (INSULIN a chain) and PROTEIN (INSULIN b chain).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (INSULIN a chain) P01315 (88-108) (INS_PIG)search Sus scrofasearch < 90% 21 100%
B PROTEIN (INSULIN b chain) P01315 (25-54) (INS_PIG)search Sus scrofasearch < 90% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01315 (88 - 108) PROTEIN (INSULIN a chain) Sus scrofa

Chain Structural classification (SCOP) Sequence family (Pfam)
A Insulin-likesearch Insulin/IGF/Relaxin familysearch
B Insulin-likesearch Insulin/IGF/Relaxin familysearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P01315) extracellular regionsearch hormone activitysearch
B (P01315) extracellular regionsearch hormone activitysearch

Chain InterPro annotation
A Insulin-likesearch Insulin, conserved sitesearch
B Insulinsearch Insulin-likesearch