Structure analysis

PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES)

X-ray diffraction
1.8Å resolution
Source organism: Sus scrofa
Assemblies composition:
hetero dimer (preferred)
hetero hexamer
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 3509.9 Å2
Buried surface area: 1629.0 Å2
Dissociation area: 761.54 Å2
Dissociation energy (ΔGdiss): 10.15 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 2
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Multimeric state: hetero hexamer
Accessible surface area: 8570.27 Å2
Buried surface area: 6843.06 Å2
Dissociation area: 2,650.8 Å2
Dissociation energy (ΔGdiss): 34.63 kcal/mol
Dissociation entropy (TΔSdiss): 25.95 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245
Assembly 3
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Multimeric state: hetero tetramer
Accessible surface area: 5660.51 Å2
Buried surface area: 4618.35 Å2
Dissociation area: 681.85 Å2
Dissociation energy (ΔGdiss): 0.04 kcal/mol
Dissociation entropy (TΔSdiss): 9.58 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242

Macromolecules

Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
InterPro:
SCOP: Insulin-like

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Chain: B
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 25-54; Coverage: 36%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like

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