Function and Biology Details
Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Guanine nucleotide binding protein (G-protein), alpha subunit
- Adenylyl cyclase class-3/4/guanylyl cyclase
- G-protein alpha subunit, group S
- Nucleotide cyclase
- G protein alpha subunit, helical insertion
- P-loop containing nucleoside triphosphate hydrolase
- Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-138244 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adenylate cyclase type 5
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 25.01 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase
Length: 220 amino acids
Theoretical weight: 25.01 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P30803 (Residues: 441-656; Coverage: 17%)
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase
Adenylate cyclase type 2
Molecule details ›
Chain: B
Length: 212 amino acids
Theoretical weight: 23.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase
Length: 212 amino acids
Theoretical weight: 23.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P26769 (Residues: 870-1081; Coverage: 19%)
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Molecule details ›
Chain: C
Length: 402 amino acids
Theoretical weight: 46.71 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: G-protein alpha subunit
Structure domains:
Length: 402 amino acids
Theoretical weight: 46.71 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P04896 (Residues: 1-394; Coverage: 100%)
Sequence domains: G-protein alpha subunit
Structure domains:
