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PDBe Entry: 1az1 
ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
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OXIDOREDUCTASE
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X-RAY DIFFRACTION
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Resolution: 1.8 Å, R-factor: 17.7%, Free R-factor: 23.2%, Spacegroup: P 21 21 21
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18/03/1998, deposition: 24/11/1997, last revision: 24/02/2009
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Harrison, D.H.T.; Bohren, K.M.; Petsko, G.A.; Ringe, D.; Gabbay, K.H.
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The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
BIOCHEMISTRY vol:36, pag:16134-16140 (1997) [PubMed ID 9405046 ]
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OXIDOREDUCTASE, ALDO-KETO REDUCTASE, INHIBITOR BINDING
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1.1.1.21 ExPASy BRENDA (A)
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Homo sapiens(human) 9606(A)
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Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase) P15121 (A)
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A
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| A |
ALDOSE REDUCTASE |
Protein |
P15121 (ALDR_HUMAN)
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315 |
99% |
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| A |
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE |
NAP
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| A |
ALRESTATIN |
ALR
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