1aya Summary

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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

The structure was published by Lee, C.H., Kominos, D., Jacques, S., et al., Schlessinger, J., Shoelson, S.E., and Kuriyan, J., in 1994 in a paper entitled "Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 1994.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) and PEPTIDE PDGFR-1009.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) P35235 (4-103) (PTN11_MOUSE)search Mus musculussearch < 90% 101 100%
B PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) P35235 (4-103) (PTN11_MOUSE)search Mus musculussearch < 90% 101 100%
P PEPTIDE PDGFR-1009 P05622 (1005-1015) (PGFRB_MOUSE)search Mus musculussearch < 90% 11 81%
Q PEPTIDE PDGFR-1009 P05622 (1005-1015) (PGFRB_MOUSE)search Mus musculussearch < 90% 11 81%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35235 (4 - 103) PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Mus musculus
P05622 (1005 - 1015) PEPTIDE PDGFR-1009 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
P, Q
Chain InterPro annotation
A, B SH2 domainsearch
P, Q