1awb Summary

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HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM

The structure was published by Ganzhorn, A.J. and Rondeau, J.-M., in 1997 in a paper entitled "Structure of an Enzyme-Substrate Complex and the Catalytic Mechanism of Human Brain Myo-Inositol Monophosphatase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MYO-INOSITOL MONOPHOSPHATASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MYO-INOSITOL MONOPHOSPHATASE P29218 (2-277) (IMPA1_HUMAN)search Homo sapienssearch 100% 276 98%
B MYO-INOSITOL MONOPHOSPHATASE P29218 (2-277) (IMPA1_HUMAN)search Homo sapienssearch 100% 276 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29218 (2 - 277) MYO-INOSITOL MONOPHOSPHATASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P29218) Inositol monophosphatase/fructose-1,6-bisphosphatase-likesearch Fructose-1,6-Bisphosphatase, subunit A, domain 1search, D-Maltodextrin-Binding Protein; domain 2search PF00459: Inositol monophosphatase familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P29218) inositol monophosphate 1-phosphatase activitysearch magnesium ion bindingsearch inositol monophosphate phosphatase activitysearch inositol monophosphate 4-phosphatase activitysearch metal ion bindingsearch hydrolase activitysearch protein homodimerization activitysearch identical protein bindingsearch manganese ion bindingsearch inositol monophosphate 3-phosphatase activitysearch lithium ion bindingsearch cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch inositol biosynthetic processsearch inositol phosphate dephosphorylationsearch phosphatidylinositol phosphorylationsearch signal transductionsearch inositol phosphate metabolic processsearch phosphatidylinositol biosynthetic processsearch phosphate-containing compound metabolic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, B Inositol monophosphatasesearch Inositol monophosphatase, conserved sitesearch Inositol monophosphatase, Lithium-sensitivesearch Inositol monophosphatase, metal-binding sitesearch