1avz Summary



The structure was published by Arold, S., Franken, P., Strub, M.P., et al., Benichou, S., Benarous, R., and Dumas, C., in 1997 in a paper entitled "The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NEGATIVE FACTOR and FYN TYROSINE KINASE.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEGATIVE FACTOR P03406 (58-206) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 151 68%
B NEGATIVE FACTOR P03406 (58-206) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 151 68%
C FYN TYROSINE KINASE P06241 (85-141) (FYN_HUMAN)search Homo sapienssearch < 90% 57 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03406 (58 - 206) NEGATIVE FACTOR Human immunodeficiency virus 1
P06241 (85 - 141) FYN TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Regulatory factor Nefsearch Nef Regulatory Factorsearch Negative factor, (F-Protein) or Nefsearch
C SH3-domainsearch SH3 Domainssearch SH3 domainsearch

Chain ID Molecular function (GO)
A, B (P03406) GTP bindingsearch

Chain InterPro annotation
A, B HIV negative factor Nefsearch HIV-1 Nef protein, core domainsearch
C SH3 domainsearch