1avz Summary

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V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN

The structure was published by Arold, S., Franken, P., Strub, M.P., et al., Benichou, S., Benarous, R., and Dumas, C., in 1997 in a paper entitled "The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NEGATIVE FACTOR and FYN TYROSINE KINASE.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEGATIVE FACTOR P03406 (58-206) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 151 68%
B NEGATIVE FACTOR P03406 (58-206) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 151 68%
C FYN TYROSINE KINASE P06241 (85-141) (FYN_HUMAN)search Homo sapienssearch < 90% 57 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03406 (58 - 206) NEGATIVE FACTOR Human immunodeficiency virus 1
P06241 (85 - 141) FYN TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Regulatory factor Nefsearch Nef Regulatory Factorsearch Negative factor, (F-Protein) or Nefsearch
C SH3-domainsearch SH3 Domainssearch SH3 domainsearch

Chain ID Molecular function (GO)
A, B (P03406) GTP bindingsearch

Chain InterPro annotation
A, B HIV negative factor Nefsearch HIV-1 Nef protein, core domainsearch
C SH3 domainsearch