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V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN

X-ray diffraction
3Å resolution
PDB entry 1avz coloured by chain, front view.
PDB entry 1avz coloured by chain, side view.
PDB entry 1avz coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Fyn and C-terminal core protein
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Multimeric state: hetero trimer
Accessible surface area: 13804.3 Å2
Buried surface area: 2137.71 Å2
Dissociation area: 1,068.86 Å2
Dissociation energy (ΔGdiss): -5.71 kcal/mol
Dissociation entropy (TΔSdiss): 21.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136957

Macromolecules

C-terminal core protein
Chains: A, B
Length: 151 amino acids
Theoretical weight: 17.57 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03406 (Residues: 58-206; Coverage: 72%)
Gene name: nef
Pfam: Negative factor, (F-Protein) or Nef
InterPro:
CATH: Nef Regulatory Factor
SCOP: Regulatory factor Nef
C-terminal core protein in PDB entry 1avz, assembly 1, front view.
C-terminal core protein in PDB entry 1avz, assembly 1, side view.
C-terminal core protein in PDB entry 1avz, assembly 1, top view.
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Tyrosine-protein kinase Fyn
Chain: C
Length: 57 amino acids
Theoretical weight: 6.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 85-141; Coverage: 11%)
Gene name: FYN
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Tyrosine-protein kinase Fyn in PDB entry 1avz, assembly 1, front view.
Tyrosine-protein kinase Fyn in PDB entry 1avz, assembly 1, side view.
Tyrosine-protein kinase Fyn in PDB entry 1avz, assembly 1, top view.
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