1avn Summary



The structure was published by Briganti, F., Mangani, S., Orioli, P., Scozzafava, A., Vernaglione, G., and Supuran, C.T., in 1997 in a paper entitled "Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytoplasmsearch microvillussearch myelin sheathsearch plasma membranesearch axonsearch extracellular vesicular exosomesearch cytosolsearch extracellular spacesearch apical part of cellsearch basolateral plasma membranesearch membranesearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch protein bindingsearch response to estrogensearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch kidney developmentsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch small molecule metabolic processsearch response to steroid hormonesearch regulation of intracellular pHsearch secretionsearch positive regulation of bone resorptionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch