1avn Summary

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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR

The structure was published by Briganti, F., Mangani, S., Orioli, P., Scozzafava, A., Vernaglione, G., and Supuran, C.T., in 1997 in a paper entitled "Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch regulation of intracellular pHsearch response to pHsearch small molecule metabolic processsearch regulation of anion transportsearch secretionsearch kidney developmentsearch positive regulation of bone resorptionsearch response to steroid hormonesearch response to organic substancesearch cellular response to fluid shear stresssearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch angiotensin-activated signaling pathwaysearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch lyase activitysearch membranesearch cytoplasmsearch cytosolsearch axonsearch basolateral plasma membranesearch apical part of cellsearch plasma membranesearch microvillussearch extracellular vesicular exosomesearch extracellular spacesearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch