1avf Summary



The structure was published by Khan, A.R., Cherney, M.M., Tarasova, N.I., and James, M.N., in 1997 in a paper entitled "Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.36 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GASTRICSIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
P GASTRICSIN P20142 (17-42) (PEPC_HUMAN)search Homo sapienssearch < 90% 26 84%
Q GASTRICSIN P20142 (17-42) (PEPC_HUMAN)search Homo sapienssearch < 90% 26 84%
A GASTRICSIN P20142 (60-388) (PEPC_HUMAN)search Homo sapienssearch < 90% 329 98%
J GASTRICSIN P20142 (60-388) (PEPC_HUMAN)search Homo sapienssearch < 90% 329 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P20142 (17 - 42) GASTRICSIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
P, Q Pepsin-likesearch A1 Propeptidesearch
A, J Pepsin-likesearch Acid Proteasessearch Eukaryotic aspartyl proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
P, Q (P20142) aspartic-type endopeptidase activitysearch proteolysissearch
A, J (P20142) aspartic-type endopeptidase activitysearch proteolysissearch

Chain InterPro annotation
P, Q Aspartic peptidase, N-terminalsearch
A, J Aspartic peptidasesearch Aspartic peptidase, active sitesearch Aspartic peptidase domainsearch