1aut Summary


Human activated protein C

The structure was published by Mather, T., Oganessyan, V., Hof, P., et al., Foundling, S., Esmon, C., and Bode, W., in 1996 in a paper entitled "The 2.8 A crystal structure of Gla-domainless activated protein C." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1996.

A re-refinement of this structure, using the same experimental data but carried out by different authors, is available as entry 3f6u.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ACTIVATED PROTEIN C.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C ACTIVATED PROTEIN C P04070 (212-461) (PROC_HUMAN)search Homo sapienssearch < 90% 250 96%
L ACTIVATED PROTEIN C P04070 (84-197) (PROC_HUMAN)search Homo sapienssearch < 90% 114 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04070 (212 - 461) ACTIVATED PROTEIN C Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C Eukaryotic proteasessearch Trypsin-like serine proteasessearch Trypsinsearch
L EGF-type modulesearch Lamininsearch Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domainsearch, Coagulation Factor Xa inhibitory sitesearch

Chain ID Molecular function (GO) Biological process (GO)
C (P04070) serine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch
L (P04070) calcium ion bindingsearch

Chain InterPro annotation
C Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
L EGF-type aspartate/asparagine hydroxylation sitesearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch EGF-like, conserved sitesearch EGF-like calcium-binding, conserved sitesearch