1aui Summary

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HUMAN CALCINEURIN HETERODIMER

The structure was published by Kissinger, C.R., Parge, H.E., Knighton, D.R., et al., Barker, J.E., Bacquet, R., and Villafranca, J.E., in 1995 in a paper entitled "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SERINE/THREONINE PHOSPHATASE 2B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE PHOSPHATASE 2B Q08209 (1-521) (PP2BA_HUMAN)search Homo sapienssearch 100% 521 72%
B SERINE/THREONINE PHOSPHATASE 2B P63098 (2-170) (CANB1_HUMAN)search Homo sapienssearch 91% 169 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q08209 (1 - 521) SERINE/THREONINE PHOSPHATASE 2B Homo sapiens
P63098 (2 - 170) SERINE/THREONINE PHOSPHATASE 2B Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q08209) Protein serine/threonine phosphatasesearch Purple Acid Phosphatase; chain A, domain 2search PF00149: Calcineurin-like phosphoesterasesearch
B (P63098) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13202: EF handsearch, PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q08209) hydrolase activitysearch protein bindingsearch phosphoprotein phosphatase activitysearch metal ion bindingsearch calcium-dependent protein serine/threonine phosphatase activitysearch calmodulin bindingsearch enzyme bindingsearch protein dimerization activitysearch protein serine/threonine phosphatase activitysearch calmodulin-dependent protein phosphatase activitysearch drug bindingsearch protein heterodimerization activitysearch calcium ion bindingsearch nucleoplasmsearch calcineurin complexsearch cytosolsearch membranesearch nucleussearch plasma membranesearch Z discsearch sarcolemmasearch nucleolussearch mitochondrionsearch cytoplasmsearch multicellular organismal response to stresssearch calcineurin-NFAT signaling cascadesearch protein dephosphorylationsearch calcium-mediated signalingsearch Fc-epsilon receptor signaling pathwaysearch cellular response to glucose stimulussearch transition between fast and slow fibersearch positive regulation of transcription from RNA polymerase II promotersearch T cell activationsearch regulation of synaptic transmissionsearch regulation of excitatory postsynaptic membrane potentialsearch dephosphorylationsearch skeletal muscle fiber developmentsearch innate immune responsesearch calcium ion transportsearch G1/S transition of mitotic cell cyclesearch response to calcium ionsearch negative regulation of insulin secretionsearch response to amphetaminesearch cellular response to drugsearch protein import into nucleussearch
B (P63098) protein domain specific bindingsearch enzyme bindingsearch metal ion bindingsearch calcium ion bindingsearch phosphoprotein phosphatase activitysearch calmodulin bindingsearch protein bindingsearch calcium-dependent protein serine/threonine phosphatase activitysearch sarcolemmasearch plasma membranesearch cytosolsearch membranesearch nucleoplasmsearch cytoplasmsearch calcineurin complexsearch patterning of blood vesselssearch protein localization to nucleussearch protein dephosphorylationsearch innate immune responsesearch intrinsic apoptotic signaling pathwaysearch lung epithelial cell differentiationsearch apoptotic processsearch Fc-epsilon receptor signaling pathwaysearch NFAT protein import into nucleussearch positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwaysearch heart developmentsearch epithelial to mesenchymal transitionsearch

Chain InterPro annotation
A Calcineurin-like phosphoesterase domain, apaH typesearch Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatasesearch Metallo-dependent phosphatase-likesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch