1au7 Summary



The structure was published by Jacobson, E.M., Li, P., Leon-del-Rio, A., Rosenfeld, M.G., and Aggarwal, A.K., in 1997 in a paper entitled "Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CONSENSUS DNA 25-MER, DNA (5'-D(*CP*TP*TP*CP*CP*TP*CP*AP*TP*GP*TP*AP*TP*AP*TP*AP*C P*AP*TP*GP*AP*GP* GP*A)-3'), and PROTEIN PIT-1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN PIT-1 P10037 (128-273) (PIT1_RAT)search Rattus norvegicussearch < 90% 146 89%
B PROTEIN PIT-1 P10037 (128-273) (PIT1_RAT)search Rattus norvegicussearch < 90% 146 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10037 (128 - 273) PROTEIN PIT-1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Homeodomainsearch, POU-specific domainsearch lambda repressor-like DNA-binding domainssearch, Homeodomain-likesearch Homeobox domainsearch, Pou domain - N-terminal to homeobox domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P10037) regulation of transcription, DNA-templatedsearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch

Chain InterPro annotation
A, B POU-specificsearch Homeobox domainsearch Homeodomain-likesearch Lambda repressor-like, DNA-binding domainsearch POU domainsearch Pituitary-specific positive transcription factor 1search Homeobox, conserved sitesearch