1at1 Summary

pdbe.org/1at1
spacer

CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H

The structure was published by Gouaux, J.E. and Lipscomb, W.N., in 1990 in a paper entitled "Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN and ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN P0A786 (2-311) (PYRB_ECOLI)search Escherichia coli K-12search 100% 310 100%
C ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN P0A786 (2-311) (PYRB_ECOLI)search Escherichia coli K-12search 100% 310 100%
B ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN P0A7F3 (1-153) (PYRI_ECOLI)search Escherichia coli K-12search 95% 153 95%
D ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN P0A7F3 (1-153) (PYRI_ECOLI)search Escherichia coli K-12search 95% 153 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P0A786 (2 - 311) ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN Escherichia coli
P0A7F3 (1 - 153) ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P0A786) Aspartate/ornithine carbamoyltransferasesearch Rossmann foldsearch PF00185: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domainsearch, PF02729: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domainsearch
B, D (P0A7F3) Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domainsearch, Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domainsearch Alpha-Beta Plaitssearch, SH3 type barrels.search PF01948: Aspartate carbamoyltransferase regulatory chain, allosteric domainsearch, PF02748: Aspartate carbamoyltransferase regulatory chain, metal binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P0A786) protein bindingsearch transferase activitysearch aspartate carbamoyltransferase activitysearch pyrimidine nucleotide biosynthetic processsearch 'de novo' UMP biosynthetic processsearch cytoplasmsearch
B, D (P0A7F3) protein bindingsearch zinc ion bindingsearch metal ion bindingsearch pyrimidine nucleotide biosynthetic processsearch cytoplasmsearch

Chain InterPro annotation
A, C Aspartate carbamoyltransferasesearch Aspartate/ornithine carbamoyltransferasesearch Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domainsearch Aspartate/ornithine carbamoyltransferase, carbamoyl-P bindingsearch
B, D Aspartate transcarbamylase regulatory subunitsearch Aspartate carbamoyltransferase regulatory subunit, C-terminalsearch Aspartate carbamoyltransferase regulatory subunit, N-terminalsearch