› 1at0

X-ray diffraction
1.9Å resolution

17-kDA fragment of hedgehog C-terminal autoprocessing domain

Released:
DOI: 10.2210/pdb1at0/pdb
PDB entry 1at0 coloured by chain, front view.
PDB entry 1at0 coloured by chain, side view.
PDB entry 1at0 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ
Cell 91 85-97 (1997)
PMID: 9335337

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein hedgehog Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 15.99 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02936 (Residues: 258-402; Coverage: 31%)
Gene names: CG4637, hh
Sequence domains: Hint module
Structure domains: Hedgehog/Intein (Hint) domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I213
Unit cell:
a: 101.54Å b: 101.54Å c: 101.54Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.275
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Communicating with Hedgehogs.
Hooper et al. (2005)
43 more

20 mentions without citation

Structural and dynamical features of inteins and implications on protein splicing.
Eryilmaz et al. (2014)
19 more