1aqd Summary

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HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

The structure was published by Murthy, V.L. and Stern, L.J., in 1997 in a paper entitled "The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN and HLA-A2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 192 93%
D HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 192 93%
G HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 192 93%
J HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 192 93%
B HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P04229 (30-227) (2B11_HUMAN)search Homo sapienssearch < 90% 198 94%
E HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P04229 (30-227) (2B11_HUMAN)search Homo sapienssearch < 90% 198 94%
H HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P04229 (30-227) (2B11_HUMAN)search Homo sapienssearch < 90% 198 94%
K HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN P04229 (30-227) (2B11_HUMAN)search Homo sapienssearch < 90% 198 94%
C HLA-A2 P01892 (127-141) (1A02_HUMAN)search Homo sapienssearch < 90% 15 93%
F HLA-A2 P01892 (127-141) (1A02_HUMAN)search Homo sapienssearch < 90% 15 93%
I HLA-A2 P01892 (127-141) (1A02_HUMAN)search Homo sapienssearch < 90% 15 93%
L HLA-A2 P01892 (127-141) (1A02_HUMAN)search Homo sapienssearch < 90% 15 93%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 217) HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN Homo sapiens
P04229 (30 - 227) HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN Homo sapiens
P01892 (127 - 141) HLA-A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D, G, J C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, E, H, K C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, F, I, L Class I Histocompatibility antigen, domains alpha 1 and 2search

Chain ID Biological process (GO) Cellular component (GO)
A, D, G, J (P01903) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
B, E, H, K (P04229) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A, D, G, J MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, E, H, K MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, F, I, L