spacer HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE
Primary citation
Title The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding.
Authors Murthy, V.L.search; Stern, L.J.search
Journal STRUCTUREsearch vol:5, pag:1385-1396 (1997), Identifiers: PubMed ID (9351812)search DOI (10.1016/S0969-2126(97)00288-8)
Abstract Class II major histocompatibility complex (MHC) proteins are cell surface glycoproteins that bind peptides and present them to T cells as part of the mechanism for detecting and responding to foreign material in the body. The peptide-binding activity exhibits allele-specific preferences for particular sidechains at some positions, although the structural basis of these preferences is not understood in detail. We have determined the 2.45 A crystal structure of the human class II MHC protein HLA-DR1 in complex with the tight binding endogenous peptide A2 (103-117) in order to discover peptide-MHC interactions that are important in determining the binding motif and to investigate conformational constraints on the bound peptide.
MeSH terms Amino Acid Sequencesearch, Binding Sitessearch, Crystallographysearch, X-Raysearch, Dimerizationsearch, HLA-DR1 Antigensearch, Humanssearch, Hydrogen Bondingsearch, Modelssearch, Molecularsearch, Molecular Sequence Datasearch, Peptidessearch, Protein Bindingsearch, Protein Conformationsearch, Protein Structuresearch, Secondarysearch, Watersearch
Secondary citations
Title Three Dimensional Structure of a Human Class II Mhc Protein Hla-Dr1 Bound to an Endogenous Peptide
Authors Murthy, V.L.search
Journal Thesis (1996) Cambridge, Ma : Massachusetts Institute of Technology (Thesis)
Title Crystal Structure of the Human Class II Mhc Protein Hla-Dr1 Complexed with an Influenza Virus Peptide
Authors Stern, L.J.search; Brown, J.H.search; Jardetzky, T.S.search; Gorga, J.C.search; Urban, R.G.search; Strominger, J.L.search; Wiley, D.C.search
Journal NATUREsearch vol:368, pag:215 (1994)
Title Three-Dimensional Structure of the Human Class II Histocompatibility Antigen Hla-Dr1
Authors Brown, J.H.search; Jardetzky, T.S.search; Gorga, J.C.search; Stern, L.J.search; Urban, R.G.search; Strominger, J.L.search; Wiley, D.C.search
Journal NATUREsearch vol:364, pag:33 (1993)
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