1aq1 Summary

pdbe.org/1aq1
spacer

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

The structure was published by Lawrie, A.M., Noble, M.E., Tunnah, P., Brown, N.R., Johnson, L.N., and Endicott, J.A., in 1997 in a paper entitled "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch ATP bindingsearch metal ion bindingsearch kinase activitysearch transferase activitysearch histone kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch DNA replicationsearch positive regulation of transcription, DNA-templatedsearch cellular response to nitric oxidesearch cell divisionsearch Ras protein signal transductionsearch histone phosphorylationsearch cellular response to DNA damage stimulussearch blood coagulationsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch meiotic cell cyclesearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of gene silencingsearch cell cyclesearch phosphorylationsearch mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic nuclear divisionsearch potassium ion transportsearch meiotic nuclear divisionsearch nucleoplasmsearch Cajal bodysearch endosomesearch cytoplasmsearch cytosolsearch centrosomesearch Y chromosomesearch condensed chromosomesearch transcription factor complexsearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch nucleussearch cytoskeletonsearch microtubule organizing centersearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch