1aq1 Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

The structure was published by Lawrie, A.M., Noble, M.E., Tunnah, P., Brown, N.R., Johnson, L.N., and Endicott, J.A., in 1997 in a paper entitled "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch transferase activitysearch metal ion bindingsearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch cell cyclesearch peptidyl-serine phosphorylationsearch cellular response to DNA damage stimulussearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch phosphorylationsearch cellular response to nitric oxidesearch mitotic nuclear divisionsearch cell divisionsearch G2/M transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of gene silencingsearch meiotic cell cyclesearch potassium ion transportsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of transcription, DNA-templatedsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch centrosome duplicationsearch positive regulation of cell proliferationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch Ras protein signal transductionsearch DNA repairsearch meiotic nuclear divisionsearch histone phosphorylationsearch mitotic cell cyclesearch nucleoplasmsearch microtubule organizing centersearch centrosomesearch nucleussearch transcription factor complexsearch Cajal bodysearch cytoplasmsearch endosomesearch chromosome, telomeric regionsearch cytosolsearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch condensed chromosomesearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch