1aq1 Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

The structure was published by Lawrie, A.M., Noble, M.E., Tunnah, P., Brown, N.R., Johnson, L.N., and Endicott, J.A., in 1997 in a paper entitled "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch kinase activitysearch nucleotide bindingsearch histone kinase activitysearch transferase activitysearch nucleoplasmsearch nucleussearch endosomesearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch Y chromosomesearch condensed chromosomesearch cytoplasmsearch chromosome, telomeric regionsearch cytoskeletonsearch transcription factor complexsearch Cajal bodysearch centrosomesearch microtubule organizing centersearch X chromosomesearch cell divisionsearch Ras protein signal transductionsearch G1/S transition of mitotic cell cyclesearch response to DNA damage stimulussearch protein phosphorylationsearch cell cyclesearch positive regulation of cell proliferationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch blood coagulationsearch positive regulation of transcription, DNA-dependentsearch meiosissearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of gene silencingsearch histone phosphorylationsearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch G2/M transition of mitotic cell cyclesearch mitosissearch mitotic cell cyclesearch phosphorylationsearch cellular response to nitric oxidesearch mitotic G2 phasesearch centrosome duplicationsearch potassium ion transportsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch