1aq1 Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

The structure was published by Lawrie, A.M., Noble, M.E., Tunnah, P., Brown, N.R., Johnson, L.N., and Endicott, J.A., in 1997 in a paper entitled "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch positive regulation of cell proliferationsearch mitotic G1 DNA damage checkpointsearch regulation of gene silencingsearch cell cyclesearch DNA repairsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to DNA damage stimulussearch G2/M transition of mitotic cell cyclesearch centrosome duplicationsearch G1/S transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of transcription, DNA-templatedsearch Ras protein signal transductionsearch blood coagulationsearch mitotic nuclear divisionsearch meiotic nuclear divisionsearch mitotic cell cyclesearch phosphorylationsearch potassium ion transportsearch DNA replicationsearch histone phosphorylationsearch meiotic cell cyclesearch cellular response to nitric oxidesearch cell divisionsearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch nucleotide bindingsearch histone kinase activitysearch cyclin bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch transferase activitysearch metal ion bindingsearch nucleoplasmsearch endosomesearch cytoplasmsearch cytoskeletonsearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch X chromosomesearch Cajal bodysearch cytosolsearch condensed chromosomesearch microtubule organizing centersearch chromosome, telomeric regionsearch nucleussearch Y chromosomesearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch