1aq1 Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

The structure was published by Lawrie, A.M., Noble, M.E., Tunnah, P., Brown, N.R., Johnson, L.N., and Endicott, J.A., in 1997 in a paper entitled "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch metal ion bindingsearch nucleotide bindingsearch protein phosphorylationsearch histone phosphorylationsearch cell cyclesearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch G2/M transition of mitotic cell cyclesearch cell divisionsearch peptidyl-serine phosphorylationsearch cellular response to nitric oxidesearch positive regulation of cell proliferationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch mitotic nuclear divisionsearch regulation of gene silencingsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch Ras protein signal transductionsearch DNA repairsearch centrosome duplicationsearch G1/S transition of mitotic cell cyclesearch blood coagulationsearch meiotic cell cyclesearch cellular response to DNA damage stimulussearch phosphorylationsearch meiotic nuclear divisionsearch mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch nucleoplasmsearch transcription factor complexsearch centrosomesearch cytosolsearch X chromosomesearch Y chromosomesearch endosomesearch chromosome, telomeric regionsearch cytoskeletonsearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch nucleussearch condensed chromosomesearch Cajal bodysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch