1aph Summary

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CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11

The structure was published by Gursky, O., Badger, J., Li, Y., and Caspar, D.L., in 1992 in a paper entitled "Conformational changes in cubic insulin crystals in the pH range 7-11." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN A CHAIN (PH 7) and INSULIN B CHAIN (PH 7).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN A CHAIN (PH 7) P01317 (85-105) (INS_BOVIN)search Bos taurussearch < 90% 21 100%
B INSULIN B CHAIN (PH 7) P01317 (25-54) (INS_BOVIN)search Bos taurussearch < 90% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01317 (85 - 105) INSULIN A CHAIN (PH 7) Bos taurus

Chain Structural classification (SCOP) Sequence family (Pfam)
A Insulin-likesearch Insulin/IGF/Relaxin familysearch
B Insulin-likesearch Insulin/IGF/Relaxin familysearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P01317) extracellular regionsearch hormone activitysearch
B (P01317) extracellular regionsearch hormone activitysearch

Chain InterPro annotation
A Insulin-likesearch Insulin, conserved sitesearch
B Insulinsearch Insulin-likesearch