spacer NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE
Primary citation
Title The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Authors Mulhern, T.D.search; Shaw, G.L.search; Morton, C.J.search; Day, A.J.search; Campbell, I.D.search
Journal STRUCTUREsearch vol:5, pag:1313-1323 (1997), Identifiers: PubMed ID (9351806)search DOI (10.1016/S0969-2126(97)00283-9)
Abstract SH2 domains are found in a variety of signal transduction proteins; they bind phosphotyrosine-containing sequences, allowing them to both recognize target molecules and regulate intramolecular kinase activity. Fyn is a member of the Src family of tyrosine kinases that are involved in signal transduction by association with a number of membrane receptors. The kinase activity of these signalling proteins is modulated by switching the binding mode of their SH2 and SH3 domains from intramolecular to intermolecular. The molecular basis of the signalling roles observed for different Src family members is still not well understood; although structures have been determined for the SH2 domains of other Src family molecules, this is the first structure of the Fyn SH2 domain.
MeSH terms Amino Acid Sequencesearch, Enzyme Stabilitysearch, Humanssearch, Modelssearch, Molecularsearch, Molecular Sequence Datasearch, Nuclear Magnetic Resonancesearch, Biomolecularsearch, Phosphopeptidessearch, Protein Bindingsearch, Protein Conformationsearch, Protein Structuresearch, Secondarysearch, Proto-Oncogene Proteinssearch, Proto-Oncogene Proteins c-fynsearch, Recombinant Proteinssearch, Sequence Alignmentsearch, Signal Transductionsearch, Substrate Specificitysearch, src Homology Domainssearch
Other entries described in this publication 1aou
Secondary citations
Title Solution Studies of the Sh2 Domain from the Fyn Tyrosine Kinase: Secondary Structure, Backbone Dynamics and Protein Association
Authors Pintar, A.search; Hensmann, M.search; Jumel, K.search; Pitkeathly, M.search; Harding, S.E.search; Campbell, I.D.search
Journal EUR.BIOPHYS.J.search vol:24, pag:371 (1996)
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