› 1amz

X-ray diffraction
1.8Å resolution

CHICKEN CITRATE SYNTHASE COMPLEX WITH NITROMETHYLDE-COA AND MALATE

Released:
DOI: 10.2210/pdb1amz/pdb
PDB entry 1amz coloured by chain, front view.
PDB entry 1amz coloured by chain, side view.
PDB entry 1amz coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Mechanisms of Enzyme-Catalyzed Deprotonation of Acetyl-Coenzyme A
Schwartz B, Vogel KW, Usher KC, Narasimhan C, Miziorko HM, Remington SJ, Drueckhammer DG
To be published

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149859 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Citrate synthase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 435 amino acids
Theoretical weight: 48.17 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P23007 (Residues: 3-80, 82-300, 302-433; Coverage: 98%)
Gene name: CS
Sequence domains: Citrate synthase, C-terminal domain
Structure domains:

Ligands and Environments


Cofactor: Ligand NMX 1 x NMX
1 bound ligand:
Ligand MLT 1 x MLT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: C2
Unit cell:
a: 104.127Å b: 78.5Å c: 58.42Å
α: 90° β: 78.93° γ: 90°
R-values:
R R work R free
0.154 0.154 not available

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