1amo Summary

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THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES

The structure was published by Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S., and Kim, J.J., in 1997 in a paper entitled "Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of NADPH-CYTOCHROME P450 REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NADPH-CYTOCHROME P450 REDUCTASE P00388 (64-678) (NCPR_RAT)search Rattus norvegicussearch 91% 615 97%
B NADPH-CYTOCHROME P450 REDUCTASE P00388 (64-678) (NCPR_RAT)search Rattus norvegicussearch 91% 615 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00388 (64 - 678) NADPH-CYTOCHROME P450 REDUCTASE Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00388) NADPH-cytochrome p450 reductase FAD-binding domain-likesearch, Cytochrome p450 reductase N-terminal domain-likesearch, NADPH-cytochrome p450 reductase-likesearch Rossmann foldsearch, Translation factorssearch, NADPH-cytochrome p450 Reductase; Chain A, domain 3search, Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) modulesearch PF00175: Oxidoreductase NAD-binding domainsearch, PF00258: Flavodoxinsearch, PF00667: FAD binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P00388) oxidation-reduction processsearch positive regulation of steroid hormone biosynthetic processsearch negative regulation of lipase activitysearch flavonoid metabolic processsearch positive regulation of monooxygenase activitysearch positive regulation of cholesterol biosynthetic processsearch cellular response to follicle-stimulating hormone stimulussearch positive regulation of chondrocyte differentiationsearch nitrate catabolic processsearch negative regulation of apoptotic processsearch response to drugsearch regulation of growth plate cartilage chondrocyte proliferationsearch carnitine metabolic processsearch regulation of cholesterol metabolic processsearch response to nutrientsearch positive regulation of smoothened signaling pathwaysearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch cellular organofluorine metabolic processsearch fatty acid oxidationsearch nitric oxide catabolic processsearch demethylationsearch internal peptidyl-lysine acetylationsearch cellular response to peptide hormone stimulussearch cellular response to gonadotropin stimulussearch NADPH-hemoprotein reductase activitysearch enzyme bindingsearch oxidoreductase activitysearch electron carrier activitysearch nitric oxide dioxygenase activitysearch cytochrome-b5 reductase activity, acting on NAD(P)Hsearch FMN bindingsearch iron ion bindingsearch hydrolase activitysearch NADP bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygensearch iron-cytochrome-c reductase activitysearch flavin adenine dinucleotide bindingsearch intracellular membrane-bounded organellesearch cytosolsearch mitochondrionsearch membranesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch

Chain InterPro annotation
A, B Flavodoxinsearch Oxidoreductase FAD/NAD(P)-bindingsearch Flavoprotein pyridine nucleotide cytochrome reductasesearch FAD-binding, type 1search Flavodoxin/nitric oxide synthasesearch Ferredoxin reductase-type FAD-binding domainsearch Riboflavin synthase-like beta-barrelsearch NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3search Flavoprotein-likesearch