1am6 Summary

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CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE

The structure was published by Scolnick, L.R., Clements, A.M., Liao, J., et al., May, J., Dean, T.R., and Christianson, D.W., in 1997 in a paper entitled "Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) secretionsearch bicarbonate transportsearch response to stresssearch one-carbon metabolic processsearch kidney developmentsearch angiotensin-mediated signaling pathwaysearch response to zinc ionsearch positive regulation of bone resorptionsearch regulation of intracellular pHsearch response to organic substancesearch response to pHsearch carbon dioxide transportsearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch response to estrogen stimulussearch response to steroid hormone stimulussearch small molecule metabolic processsearch metal ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch plasma membranesearch microvillussearch cytoplasmsearch cytosolsearch membranesearch basolateral plasma membranesearch axonsearch apical part of cellsearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2/13search Carbonic anhydrase, alpha-classsearch