1alu Summary

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HUMAN INTERLEUKIN-6

The structure was published by Somers, W., Stahl, M., and Seehra, J.S., in 1997 in a paper entitled "1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of INTERLEUKIN-6. This molecule has the UniProt identifier P05231 (IL6_HUMAN)search. The sample contained 186 residues which is < 90% of the natural sequence. Out of 186 residues 154 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERLEUKIN-6 P05231 (28-212) (IL6_HUMAN)search Homo sapienssearch 91% 186 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05231 (28 - 212) INTERLEUKIN-6 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05231) Long-chain cytokinessearch Growth Hormone; Chain: A;search PF00489: Interleukin-6/G-CSF/MGF familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P05231) cytokine activitysearch interleukin-6 receptor bindingsearch extracellular regionsearch immune responsesearch

Chain InterPro annotation
A Interleukin-6/Interleukin-23/GCSF/MGFsearch Interleukin-6search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch