1alk Summary

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REACTION MECHANISM OF ALKALINE PHOSPHATASE BASED ON CRYSTAL STRUCTURES. TWO METAL ION CATALYSIS

The structure was published by Kim, E.E. and Wyckoff, H.W., in 1991 in a paper entitled "Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ALKALINE PHOSPHATASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALKALINE PHOSPHATASE P00634 (23-471) (PPB_ECOLI)search Escherichia coli K-12search 99% 449 100%
B ALKALINE PHOSPHATASE P00634 (23-471) (PPB_ECOLI)search Escherichia coli K-12search 99% 449 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00634 (23 - 471) ALKALINE PHOSPHATASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00634) Alkaline phosphatasesearch Alkaline Phosphatase, subunit Asearch PF00245: Alkaline phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P00634) zinc ion bindingsearch catalytic activitysearch phosphatase activitysearch oxidoreductase activity, acting on phosphorus or arsenic in donorssearch alkaline phosphatase activitysearch protein bindingsearch hydrolase activitysearch hydrogenase (acceptor) activitysearch metal ion bindingsearch magnesium ion bindingsearch dephosphorylationsearch metabolic processsearch periplasmic spacesearch

Chain InterPro annotation
A, B Alkaline phosphatasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Alkaline phosphatase, active sitesearch