1aj9 Summary

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R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S

The structure was published by Vasquez, G.B., Ji, X., Fronticelli, C., and Gilliland, G.L., in 1998 in a paper entitled "Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch membranesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxygen transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch bicarbonate transportsearch
B (P68871) cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch heme bindingsearch protein bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch iron ion bindingsearch renal absorptionsearch blood coagulationsearch oxygen transportsearch oxidation-reduction processsearch platelet aggregationsearch regulation of blood vessel sizesearch nitric oxide transportsearch regulation of blood pressuresearch positive regulation of cell deathsearch transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch