1aj9 Summary

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R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S

The structure was published by Vasquez, G.B., Ji, X., Fronticelli, C., and Gilliland, G.L., in 1998 in a paper entitled "Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch membranesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch oxygen transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch transportsearch
B (P68871) oxygen bindingsearch heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch oxygen transportsearch blood coagulationsearch renal absorptionsearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch nitric oxide transportsearch protein heterooligomerizationsearch bicarbonate transportsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch